Cox models were used to compare outcomes between treatment groups.A total of 7,893 matched pairs were included; mean (SD) follow-up was 6.3 (5.4) months. En poursuivant votre navigation sur ce site ou en cliquant sur le bouton "J'accepte", vous consentez à ce que Vidal France et ses partenaire utilisent des cookies à des fins de mesure d'audience, de personnalisation des contenus, d'interaction avec les réseaux sociaux, ainsi que pour vous proposer des publicités adaptées à vos centres d’intérêts. ).Faculty of Medicine and Health Sciences, University of Nottingham, UK (M.T. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. a transfer to a third party for commercial and uncommercial reasons does not take place. ), University of Oxford, UK.Medical Research Council Population Health Research Unit (R.H., P.K.J., W.G.H., B.C.S., M.H., M.J.L., C.B.

Hypertension artérielle There was no excess of discontinuations because of serious adverse events, nonserious adverse reactions, or other reasons in those allocated sacubitril/valsartan (At 12 months, the mean (SE) mGFR was 29.8 (0.5) mL/min/1.73 mWhere the difference between mGFR and central eGFR at the corresponding time point was more extreme than the first or 99th percentile of the distribution of differences, the value of mGFR was set to missing.

), University of Oxford, UK.Medical Research Council Population Health Research Unit (R.H., P.K.J., W.G.H., B.C.S., M.H., M.J.L., C.B. Similar additional reductions in blood pressure compared with RAS inhibition have been shown in populations with heart failure or hypertension.Sacubitril/valsartan was generally well tolerated, and no major hazards were observed; although there were numerically more nonserious adverse reactions in the sacubitril/valsartan group, this difference was not statistically significant. *Values are absolute differences in arithmetic means (SE). McMurray and al. GFR was measured at or just before the 12-month visit, and paper results of all GFR measurements were sent to the coordinating center for verification blind to treatment allocation. Sacubitril/valsartan was also found to reduce blood pressure and biomarkers of cardiovascular risk (troponin I and NT-proBNP) compared with irbesartan.The kidney function results from the UK HARP-III trial do not confirm findings from the analyses of kidney disease progression outcomes from other NEPi trials among patients with heart failure. ), University of Oxford, UK.Clinical Trial Service Unit (R.H., P.K.J., N.S., W.G.H., B.C.S., L.B., M.H., M.J.L., C.B. No difference in risk of hyperkalemia was observed (0.89 vs. 0.84 events per 100 person-years; HR: 1.05, 95% CI: 0.66 to 1.67; p = 0.84). All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.We use cookies to help provide and enhance our service and tailor content and ads. A lower risk of the primary outcome with sacubitril-valsartan was observed in white patients (HR: 0.83, 95% CI: 0.76 to 0.90) but not black patients (21% of population, HR: 1.00, 95% CI: 0.88 to 1.15; interaction p = 0.032). Study average NT-proBNP concentrations were 18% (-25 to -11%) lower and troponin I levels were 16% (-23% to -8%) lower among participants assigned sacubitril/valsartan (Using data from 87 participants who had taken their last dose of sacubitril/valsartan 10 to 16 hours previously, no significant determinants of sacubitril or valsartan concentration were identified (Allocation to sacubitril/valsartan had no significant effect on fatal serious adverse events (1 [0.5%] versus 1 [0.5%]) or on any nonfatal serious adverse events (61 [29.5%] versus 59 [28.5%]; rate ratio, 1.07; 95% CI, 0.75–1.53; Based on local laboratory measurements.

Title: ENTRESTO (sacubitril/valsartan) Author: LE JOUAN Melisande Last modified by: CHEN Marina Created Date: 10/11/2018 1:27:00 PM Company: APHP Other titles Email © American Heart Association, Inc. All rights reserved. Study visits were scheduled at 1, 3, 6, 9, and 12 months after randomization (and additional visits arranged where necessary to monitor participant safety).

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